Ashok (Saif Ali Khan) and Kumar (Riteish Deshmukh) are best friends, whereas Shanaya (Tamannaah Bhatia) and Mishti (Bipasha Basu) are their love interests. Ashok’s father is a multi-millionaire but has been in a coma for the last six years, while his wicked maternal uncle, Kunwar Amarnath Singh a.k.a. Mamaji (Ram Kapoor) teams up with an evil doctor, Dr. Khan (Nawab Shah) to get rid of Ashok and take over all his property. During a board meeting, Mamaji mixes medicine in Ashok and Kumar’s drink and they both start behaving like dogs.
They are taken to a mental asylum for treatment by Dr. Shivani (Esha Gupta), who soon realizes the truth and promises to discharge them. But fate takes a twist as two lookalikes of Ashok and Kumar being treated in the same hospital’s ‘B’ ward, who works for Bijlani (Chunkey Pandey), a cocaine smuggler, are accidentally released instead of the true ones. Shanaya and Mishti take them to Ashok’s mansion where Singh understands the whole mix-up and plans to use the duplicate Ashok to become the owner of the whole business empire. Now the true Ashok and Kumar also come to know of Mamaji’s evil plan but are stuck in the asylum. They are offered help by one of the ward boys, Cyrus (Darshan Jariwala), who takes them to a secret ward ‘C’ to meet ‘Johnny’ who is a look-alike of Mamaji but has a dangerous habit of attacking people who sneeze in front of him. Ashok and Kumar plan revenge against Singh with the help of Johnny but get caught by the warden Y. M. Raj (Satish Shah) before they can escape from the asylum. Y. M. Raj prepares to punish them but accidentally sneezes in front of them. Angered by this, Johnny beats him black and blue, thus helping the three escape.
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