Child psychologist Catherine Deane (Jennifer Lopez) is hired to conduct an experimental virtual reality treatment for coma patients: a “Neurological Cartography and Synaptic Transfer System” device managed by doctors Henry West and Miriam Kent (Dylan Baker and Marianne Jean-Baptiste) that allows her to enter a comatose mind and attempt to coax them into consciousness. The technology is funded by the parents of her patient, Edward Baines (Colton James), a young boy left comatose by a viral infection that causes an unusual form of schizophrenia. Despite Deane’s lack of progress, West and Kent reject Deane’s suggestion to reverse the feed to bring Baines into her mind, fearing the consequences of him experiencing an unfamiliar world.
Serial killer Carl Rudolph Stargher (Vincent D’Onofrio) traps his victims in a cell in the form of a glass enclosure that slowly fills with water by means of an automatic timer, then uses a hoist in his basement to suspend himself above their bodies while watching the recorded video of their deaths. He succumbs to the same schizophrenic illness and falls into a coma just as the FBI identifies him, leaving them without any leads as to the location of his latest victim, Julia Hickson (Tara Subkoff). After learning of this experimental technology, Agent Peter Novak (Vince Vaughn) persuades Deane to enter Stargher’s mind and discover Hickson’s location.
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